2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-130500
    Br-PEG3-CH2COOH 1346502-15-5
    Br-PEG3-CH2COOH (compound 28) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Br-PEG3-CH2COOH
  • HY-132071
    Methylamino-PEG3-t-butyl ester 217817-03-3
    Methylamino-PEG3-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Methylamino-PEG3-t-butyl ester
  • HY-W096140
    Propargyl-PEG5-1-o-(b-cyanoethyl-n,n-diisopropyl)phosphoramidite 1682657-14-2
    Propargyl-PEG5-1-o-b-cyanoethyl-nn-diisopropylphosphoramidite is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG5-1-o-(b-cyanoethyl-n,n-diisopropyl)phosphoramidite is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG5-1-o-(b-cyanoethyl-n,n-diisopropyl)phosphoramidite
  • HY-140609
    m-PEG3-Sulfone-PEG3-Boc 2055041-00-2
    m-PEG3-Sulfone-PEG3-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG3-Sulfone-PEG3-Boc
  • HY-140332
    Diethyl 8-bromooctylphosphonate 124939-70-4
    Diethyl 8-bromooctylphosphonate is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    Diethyl 8-bromooctylphosphonate
  • HY-138720
    Fmoc-PEG9-NHS ester
    Fmoc-PEG9-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-PEG9-NHS ester
  • HY-141035
    N-(m-PEG4)-N'-(PEG2-acid)-Cy5 2107273-24-3
    N-(m-PEG4)-N'-(PEG2-acid)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-(m-PEG4)-N'-(PEG2-acid)-Cy5
  • HY-140592
    Azido-PEG3-S-PEG4-t-butyl ester 2055041-19-3
    Azido-PEG3-S-PEG4-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-S-PEG4-t-butyl ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG3-S-PEG4-t-butyl ester
  • HY-140729
    Thiol-PEG3400-CH2COOH
    Thiol-PEG3400-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Thiol-PEG3400-CH2COOH
  • HY-138475
    Boc-PEG2-ethoxyethane-PEG2-benzyl 2111836-22-5
    Boc-PEG2-ethoxyethane-PEG2-benzyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-PEG2-ethoxyethane-PEG2-benzyl
  • HY-141259
    C-NH-Boc-C-Bis-(C1-PEG1-PFP) 1807521-01-2
    C-NH-Boc-C-Bis-(C1-PEG1-PFP) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    C-NH-Boc-C-Bis-(C1-PEG1-PFP)
  • HY-W056066
    tert-Butyl ((3-(aminomethyl)cyclobutyl)methyl)carbamate 1363382-06-2
    tert-Butyl ((3-(aminomethyl)cyclobutyl)methyl)carbamate (3-Aminomethyl-1-(boc-aminomethyl)cyclobutane) is a PROTAC linker that can be used in the synthesis of PROTACs.
    tert-Butyl ((3-(aminomethyl)cyclobutyl)methyl)carbamate
  • HY-140544
    N-(Azido-PEG2)-N-Fluorescein-PEG3-acid 2086689-04-3
    N-(Azido-PEG2)-N-Fluorescein-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG2)-N-Fluorescein-PEG3-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(Azido-PEG2)-N-Fluorescein-PEG3-acid
  • HY-138733
    Propargyl-PEG13-Boc
    Propargyl-PEG13-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG13-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG13-Boc
  • HY-140524
    N-(Azido-PEG2)-N-Boc-PEG3-acid 2086689-01-0
    N-(Azido-PEG2)-N-Boc-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG2)-N-Boc-PEG3-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(Azido-PEG2)-N-Boc-PEG3-acid
  • HY-168276
    Boc-Nonanol 3036972-61-6
    Boc-Nonanol is a PROTAC linker. Boc-Nonanol can be used in the synthesis of PROTAC TRIB2 degrader-1 (HY-168274) .
    Boc-Nonanol
  • HY-130984
    Azido-PEG1-CH2COO-Cl 79598-49-5
    Azido-PEG1-CH2COO-Cl (compound 43a) is an alkyl/ether-based PROTAC linker. Azido-PEG1-CH2COO-Cl can be used in the synthesis of PROTAC BRD4 Degrader-1 (HY-133131). Azido-PEG1-CH2COO-Cl is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG1-CH2COO-Cl
  • HY-140229
    m-PEG36-amine
    m-PEG36-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG36-amine
  • HY-174222
    4-Piperidineethanol-piperidine-Boc 3056570-35-2
    4-Piperidineethanol-piperidine-Boc is a PROTAC linker can be used in the synthesis of PROTAC BRD4 Degrader-31 (HY-174210).
    4-Piperidineethanol-piperidine-Boc
  • HY-138459
    Propargyl-PEG9-THP
    Propargyl-PEG9-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG9-THP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG9-THP
PROTAC Linkers Isoform Comparison

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